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e454

www.thelancet.com/haematology

Vol 4 October 2017

instance of age, the systematic review done by Simon

and colleagues

5

only included some of the RCTs in which

the median age of patients was more than 64 years.

Their analysis excluded a substantial proportion of

elderly patients, both within the eligible trials missing

from their review and in the other trials identi ed by

the Cochrane review.

3

Inclusion of these patients would

provide valuable additional data in developing the

evidence base for this important issue.

*Michael F Murphy, Lise Estcourt, Lawrence TimGoodnough

NHS Blood and Transplant Centre, John Radcli e Hospital, Oxford

OX3 9BQ, UK (MFM, LE); Oxford National Institute for Health

Research Biomedical Research Centre, Oxford University Hospitals,

University of Oxford, Oxford, UK (MFM, LE); and Department of

Pathology and Department of Medicine (Hematology), Stanford

University, Stanford, CA, USA (LTG)

mike.murphy@nhsbt.nhs.uk

We declare no competing interests.

1

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3

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4

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5

Simon GI, Craswell A,ThomO, FungYL. Outcomes of restrictive versus

liberal transfusion strategies in older adults from nine randomised

controlled trials: a systematic review and meta-analysis.

Lancet Haematol

2017; published online September 11.

http://dx.doi. org/10.1016/S2352-3026(17)30141-2

6

Tinegate H, Pendry K, Murphy MF, et al.Where do all the red blood cells

(RBCs) go? Results of a survey of RBC use in England and NorthWales in

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