Vol 4 October 2017
instance of age, the systematic review done by Simon
only included some of the RCTs in which
the median age of patients was more than 64 years.
Their analysis excluded a substantial proportion of
elderly patients, both within the eligible trials missing
from their review and in the other trials identi ed by
the Cochrane review.
Inclusion of these patients would
provide valuable additional data in developing the
evidence base for this important issue.
*Michael F Murphy, Lise Estcourt, Lawrence TimGoodnough
NHS Blood and Transplant Centre, John Radcli e Hospital, Oxford
OX3 9BQ, UK (MFM, LE); Oxford National Institute for Health
Research Biomedical Research Centre, Oxford University Hospitals,
University of Oxford, Oxford, UK (MFM, LE); and Department of
Pathology and Department of Medicine (Hematology), Stanford
University, Stanford, CA, USA (LTG)firstname.lastname@example.org
We declare no competing interests.
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Goodnough LT, Murphy MF. Do liberal blood transfusions cause more harm
Carson JL, Stanworth SJ, Roubinian N, et al.Transfusion thresholds and
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Carson JL, Guyatt G, Heddle NM, et al. Clinical practice guidelines from the
AABB: red blood cell transfusion thresholds and storage.
Simon GI, Craswell A,ThomO, FungYL. Outcomes of restrictive versus
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controlled trials: a systematic review and meta-analysis.
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